Chitosan scaffolds1/18/2024 ![]() ![]() Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.The aim of the experiment was to compare the compatibility of scaffolds based on chitosan with gallic acid, ferulic acid, or tannic acid using the in vivo method. ![]() One-step fabrication of apatite-chitosan scaffold as a potential injectable construct for bone tissue engineering. Chitosan-based scaffolds modified by gallic acid, ferulic acid, and tannic acid were fabricated. Jahan, K., Mekhail, M., & Tabrizian, M.Dental Medicine and Oral Health Sciences.in vitro studies showed good cell adhesion and morphology, as well as potential use for bone tissue engineering applications. The scaffolds were prepared by freeze-drying method and cross-linked using different types of cross-linkers. Rheology showed a viscoelastic behavior of the solutions and the elastic behavior of the sponges, and therefore their injectability potential. The scaffolds, composed of chitosan/collagen type I/nanohydroxyapatite (Chi/Coll/nHA) as the most attractive components in bone tissue engineering, were analyzed. All the groups of scaffolds exhibited high porosity (>65) and good swelling ratio suitable for myocardial tissue engineering. Morphological analyses revealed an interconnected, highly porous structure, with pore size ranging from 200 nm-200 μm that was maintained even with the biominerals. The collagen/chitosan scaffolds prepared with various crosslinking agents were fabricated and evaluated for physical characteristics, biocompatibility and contractile performance. Spectroscopy showed the formation of ionic bonds between chitosan and the apatites. These soft gels could retain up to 4 times their weight in water. The gelling of chitosan via the crosslinker occurs in <4 s as measured by impedance spectroscopy. In this review, we mainly focus on the recent advances in chitosan-based scaffolds for facilitated endogenous bone regeneration (Figure 1). In this work, carbon nanofibers were used as doping material to develop a highly conductive chitosan-based composite. Chitosan is especially attractive as a bone scaffold material because it supports the attachment and proliferation of osteoblast cells as well as formation of. The scaffolds were fabricated by mixing chitosan, adenosine diphosphate and biominerals in an ‘all-in-one-step’ procedure. The chitosan scaffolds and their degradation products were non-toxic toward hBMSCs and allowed cell adhesion, spreading, and proliferation. This work aimed to develop a new injectable and in-situ gelling soft scaffold with chitosan and apatites through a rapid purine-crosslinking reaction. Biomineralization of soft scaffolds is a new venture in bone tissue engineering. ![]()
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